2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-169575
    PARP1-IN-36 1606996-12-6 98%
    PARP1-IN-36 (compound 11) is a 4-carboxamido-isoindolinone derivative and a selective PARP-1 inhibitor with a Kd < 0.01 μM. PARP1-IN-36 can be utilized in cancer, cardiovascular diseases, nervous system injury and inflammation research.
    PARP1-IN-36
  • HY-169576
    LRRK2-IN-16 852375-30-5 98%
    LRRK2-IN-16 (compound 25) is a LRRK2 kinase inhibitor with an IC50 < 5 μM. LRRK2-IN-16 can be utilized in neurodegenerative disorders and autoimmune disorders research.
    LRRK2-IN-16
  • HY-169577
    Casein kinase 1δ-IN-18 522626-08-0 98%
    Casein kinase 1δ-IN-18 (compound 660) is a casein kinase 1δ (CK1δ) inhibitor. Casein kinase 1δ-IN-18 can be utilized in neurodegenerative disorders research.
    Casein kinase 1δ-IN-18
  • HY-169609
    JNK-IN-22 771503-50-5 98%
    JNK-IN-22 (Compound 58) is a JNK-1 inhibitor.
    JNK-IN-22
  • HY-169611
    Serotonin maleate 18525-25-2 98%
    Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
    Serotonin maleate
  • HY-169614
    2002-G12 313666-93-2 98%
    2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. 2002-G12 can be used in Alzheimer's research.
    2002-G12
  • HY-169632
    GSK3β-IN-1 757198-76-8 98%
    GSK3β-IN-1 (compound 1) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=65 nM), which can be used in the study of Alzheimer's disease.
    GSK3β-IN-1
  • HY-169668
    WAY-606344 380423-28-9 98%
    WAY-606344 (Compound 97) is a Casein kinase 1δ inhibitor. WAY-606344 is promising for research of Alzheimer's disease.
    WAY-606344
  • HY-169689
    Casein kinase 1δ-IN-19 782452-74-8 98%
    Casein kinase 1δ-IN-19 (compound 492) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-19 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-19
  • HY-169690
    Casein kinase 1δ-IN-20 757224-44-5 98%
    Casein kinase 1δ-IN-20 (compound 427) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-20 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-20
  • HY-169692
    Casein kinase 1δ-IN-21 782457-22-1 98%
    Casein kinase 1δ-IN-21 (compound 501) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-21 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-21
  • HY-169701
    Casein kinase 1δ-IN-22 756849-12-4 98%
    Casein kinase 1δ-IN-22 (compound 484) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-22 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-22
  • HY-169702
    Casein kinase 1δ-IN-23 729579-66-2 98%
    Casein kinase 1δ-IN-23 (compound 423) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-22 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-23
  • HY-169704
    Ogerin analogue 1 1125453-08-8 98%
    Ogerin analogue 1 (compound 20) is a structural analog of Ogerin (HY-110279). Ogerin analogue 1 is generally used as a negative control.
    Ogerin analogue 1
  • HY-169705
    Casein kinase 1δ-IN-24 326034-30-4 98%
    Casein kinase 1δ-IN-24 (compound 489) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-24 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-24
  • HY-169706
    Casein kinase 1δ-IN-25 753468-25-6 98%
    Casein kinase 1δ-IN-25 (compound 487) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-25 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-25
  • HY-169709
    Casein kinase 1δ-IN-26 756857-71-3 98%
    Casein kinase 1δ-IN-26 (compound 505) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-26 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-26
  • HY-169719
    CK1δ-IN-6 565167-37-5 98%
    CK1δ-IN-6 (Compound 303) is a Casein kinase 1δ inhibitor. CK1δ-IN-6 is promising for research of Alzheimer's disease.
    CK1δ-IN-6
  • HY-169736
    JNK-IN-21 756849-36-2 98%
    JNK-IN-21 (Compound 62) is a JNK-1 inhibitor.
    JNK-IN-21
  • HY-169742
    Epibatidine 140111-52-0 98%
    Epibatidine is a α7nACh agonist with a Kd of 100 nM. Epibatidine can be used in the study of Alzheimer's, Parkinson's and schizophrenia.
    Epibatidine
Cat. No. Product Name / Synonyms Application Reactivity